Which drug is known for pulling fluid out of tissues?

Mannitol is a hyperosmotic agent that is primarily used to manage cerebral edema and elevated intracranial pressure by drawing fluid out of tissues into the extracellular space, effectively reducing swelling. It does this by increasing the osmolarity of the blood, which causes osmotic diuresis. When mannitol is administered, it interacts with the renal tubules and increases urine production by pulling water out of tissues, leading to increased urinary output. This is particularly useful in emergency situations where rapid reduction of tissue swelling is needed.

In contrast, while Lasix (furosemide) and hydrochlorothiazide are both diuretics that promote the excretion of fluid from the body, they do not have the same mechanism of pulling fluid out of tissues as mannitol does. Lasix, for instance, works primarily by inhibiting sodium reabsorption in the loop of Henle of the kidney, which leads to increased urine production, but it doesn't specifically target fluid from the tissues in the same manner.

Therefore, the key distinction lies in mannitol's unique property of extracting fluid from tissues through osmotic pressure rather than simply promoting diuresis through renal filtration, making it the correct choice for the question.